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Phenotypes Associated with This Genotype
Genotype
MGI:3665567
Allelic
Composition		 En1tm2(cre)Gld/En1+
Gli1tm2Alj/Gli1tm2Alj
Gli2tm1Alj/Gli2tm6Alj
Genetic
Background		 involves: 129S1/Sv * 129S6/SvEvTac * 129X1/SvJ * Swiss Webster
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
En1tm2(cre)Gld mutation (0 available); any En1 mutation (32 available)
Gli1tm2Alj mutation (1 available); any Gli1 mutation (48 available)
Gli2tm1Alj mutation (0 available); any Gli2 mutation (169 available)
Gli2tm6Alj mutation (1 available); any Gli2 mutation (169 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system
abnormal cerebellum morphology ( J:108507 )
• cerebellum has decreased number of fissures compared to conditional Gli2 knockouts
abnormal cerebellum development ( J:108507 )
• only the five cardinal lobes of cerebellum can be discerned; other lobules do not form
abnormal cerebellar foliation ( J:108507 )
• decreased number of lobules (abnormal foliation) is observed

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
04/23/2024
MGI 6.23 		The Jackson Laboratory