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Phenotypes Associated with This Genotype
Genotype
MGI:3665566
Allelic
Composition
F11tm1Gjb/F11tm1Gjb
Genetic
Background
involves: 129X1/SvJ * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
F11tm1Gjb mutation (1 available); any F11 mutation (1 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
nervous system
• after transient middle cerebral artery occlusion, the volume of infarcted brain is less than in controls
• reduced fibrin formation in ischemic vessels

homeostasis/metabolism
• defect in the formation and stabilization of platelet-rich occlusive thrombi after injury
• activated partial thromboplastin times markedly prolonged (moderately so in heterozygotes)
• tail bleeding times slightly but not significantly increased over controls
• after transient middle cerebral artery occlusion, the volume of infarcted brain is less than in controls
• reduced fibrin formation in ischemic vessels

hematopoietic system
• defect in the formation and stabilization of platelet-rich occlusive thrombi after injury

Mouse Models of Human Disease
DO ID OMIM ID(s) Ref(s)
factor XI deficiency DOID:2229 OMIM:612416
J:40270


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
03/13/2019
MGI 6.13
The Jackson Laboratory