Phenotypes Associated with This Genotype

Genotype
MGI:3665497

• Allelic Composition: Tg(Shh)#Dje/0
• Genetic Background: involves: Swiss Webster

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

nervous system

abnormal cerebellum morphology ( J:94461 , J:108507 )

• cerebellum is larger than wild-type especially in the AP axis in adult mutant (J:94461)

• mice develop larger cerebellum than controls (J:108507)

abnormal cerebellum external granule cell layer morphology ( J:94461 )

• at P14, EGL contains 3-4 cell layers vs a single layer in wild-type

• EGL persists until P16 while in normal littermates it is gone

abnormal cerebellar cortex morphology ( J:94461 )

• lobes in vermis and hemispheres are larger than in wild-type in adults

abnormal cerebellar granule layer morphology ( J:94461 , J:108507 )

• IGL is thicker and irregular compared to wild-type in lobes III, IV, V, and IX; overall, IGL in mutants is 30% larger than in wild-type in adults (J:94461)

• IGL surrounding primary fissure is irregular with distinct bulges (J:94461)

• IGL at P28 is more irregular than at P14 (J:94461)

• IGL is thicker and irregular compared to wild-type (J:108507)

cellular

abnormal cell proliferation ( J:94461 )

• cell proliferation is detected in mutant EGL at P16 while in wild-type it stops at P14