Phenotypes Associated with This Genotype

Genotype
MGI:3665488

• Allelic Composition: Tg(Shh)#Dje/0
• Genetic Background: involves: CD-1

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

head bobbing ( J:79100 )

• observed in transgenic mice

hyperactivity ( J:79100 )

• observed in transgenic mice

circling ( J:79100 )

• circling (related to vestibular apparatus dysfunction) is observed

hearing/vestibular/ear

abnormal cochlear sensory epithelium morphology ( J:79100 )

• at E15.5, only 1 or 2 sensory patches are observed

abnormal scala media morphology ( J:79100 )

absent semicircular canals ( J:79100 )

• identifiable canals are absent at E15.5

abnormal inner ear vestibule morphology ( J:79100 )

• identifiable utricle and saccule are absent at E15.5

absent utricle ( J:79100 )

absent vestibular saccule ( J:79100 )

nervous system

abnormal vestibulocochlear ganglion morphology ( J:79100 )

• number of neurons contributing to cochleovestibular ganglion is increased 2 fold over wild-type at E10.5