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Phenotypes Associated with This Genotype
Genotype
MGI:3665287
Allelic
Composition
Tg(PRNP-APPSweInd)8Dwst/?
Genetic
Background
involves: 129S6/SvEvTac
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No mouse lines available in IMSR.
See publication links below for author information.
phenotype observed in females
phenotype observed in males
N normal phenotype
nervous system
• observed at 16 and 20 weeks of age in hippocampus and cortex
• level of brain amyloid beta peptide 42 is predominant over 40; levels increase dramatically after 16 weeks of age

homeostasis/metabolism
• observed at 16 and 20 weeks of age in hippocampus and cortex
• level of brain amyloid beta peptide 42 is predominant over 40; levels increase dramatically after 16 weeks of age
• elevated plasma triglyceride levels observed between 9 and 15 weeks of age
• VLDL production rates are increased as early as 9 weeks of age and remain elevated up to 22 weeks of age
• plasma free fatty acid levels were unchanged

Mouse Models of Human Disease
DO ID OMIM ID(s) Ref(s)
Alzheimer's disease DOID:10652 J:113199


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
03/19/2024
MGI 6.23
The Jackson Laboratory