About   Help   FAQ
Phenotypes Associated with This Genotype
Genotype
MGI:3665287
Allelic
Composition
Tg(PRNP-APPSweInd)8Dwst/?
Genetic
Background
involves: 129S6/SvEvTac
Find Mice Using the International Mouse Strain Resource (IMSR)
No mouse lines available in IMSR.
See publication links below for author information.
phenotype observed in females
phenotype observed in males
N normal phenotype
nervous system
• observed at 16 and 20 weeks of age in hippocampus and cortex (J:113199)
• level of brain amyloid beta peptide 42 is predominant over 40; levels increase dramatically after 16 weeks of age (J:113199)
• observed at 16 and 20 weeks of age in hippocampus and cortex (J:113199)
• level of brain amyloid beta peptide 42 is predominant over 40; levels increase dramatically after 16 weeks of age (J:113199)

homeostasis/metabolism
• elevated plasma triglyceride levels observed between 9 and 15 weeks of age (J:113199)
• elevated plasma triglyceride levels observed between 9 and 15 weeks of age (J:113199)
• VLDL production rates are increased as early as 9 weeks of age and remain elevated up to 22 weeks of age (J:113199)
• plasma free fatty acid levels were unchanged (J:113199)
• VLDL production rates are increased as early as 9 weeks of age and remain elevated up to 22 weeks of age (J:113199)
• plasma free fatty acid levels were unchanged (J:113199)
• observed at 16 and 20 weeks of age in hippocampus and cortex (J:113199)
• level of brain amyloid beta peptide 42 is predominant over 40; levels increase dramatically after 16 weeks of age (J:113199)
• observed at 16 and 20 weeks of age in hippocampus and cortex (J:113199)
• level of brain amyloid beta peptide 42 is predominant over 40; levels increase dramatically after 16 weeks of age (J:113199)

Mouse Models of Human Disease
OMIM ID Ref(s)
Alzheimer Disease; AD 104300 J:113199


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
02/02/2016
MGI 6.02
The Jackson Laboratory