Mouse Genome Informatics
tg
    Tg(PRNP-APPSweInd)8Dwst/?
involves: 129S6/SvEvTac
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
       
nervous system
• observed at 16 and 20 weeks of age in hippocampus and cortex
• level of brain amyloid beta peptide 42 is predominant over 40; levels increase dramatically after 16 weeks of age

homeostasis/metabolism
• elevated plasma triglyceride levels observed between 9 and 15 weeks of age
• VLDL production rates are increased as early as 9 weeks of age and remain elevated up to 22 weeks of age
• plasma free fatty acid levels were unchanged

other phenotype
• observed at 16 and 20 weeks of age in hippocampus and cortex
• level of brain amyloid beta peptide 42 is predominant over 40; levels increase dramatically after 16 weeks of age

Mouse Models of Human Disease
OMIM IDRef(s)
Alzheimer Disease; AD 104300 J:113199