Phenotypes Associated with This Genotype

Genotype
MGI:3665229

• Allelic Composition: \Tg(Cd8b1)46Erob/0
• Genetic Background: involves: 129S4/SvJae * C57BL/6 * CBA

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

abnormal T cell subpopulation ratio ( J:110916 )

• CD8 to CD4 ratio is 1.8 fold lower than in wild-type

decreased T cell number ( J:110916 )

• there is a lack of mature CD8-lineage T cells

decreased thymocyte number ( J:110916 )

• mice have 2-fold fewer CD8-lineage thymocytes compared to wild-type; there is a lack of mature CD8-lineage T cells

hematopoietic system

abnormal T cell subpopulation ratio ( J:110916 )

• CD8 to CD4 ratio is 1.8 fold lower than in wild-type

decreased T cell number ( J:110916 )

• there is a lack of mature CD8-lineage T cells

decreased thymocyte number ( J:110916 )

• mice have 2-fold fewer CD8-lineage thymocytes compared to wild-type; there is a lack of mature CD8-lineage T cells

homeostasis/metabolism

abnormal enzyme/coenzyme activity ( J:110916 )

• thymocytes show 2-fold reduction in CD8-associated Lck activity vs wild-type

• activity of Lck is reduced but significant levels are detected in mutants; there is a slight reduction in CD8a-associated activity compared to wild-type

endocrine/exocrine glands

decreased thymocyte number ( J:110916 )

• mice have 2-fold fewer CD8-lineage thymocytes compared to wild-type; there is a lack of mature CD8-lineage T cells