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Phenotypes Associated with This Genotype
Genotype
MGI:3664797
Allelic
Composition
Elovl4tm1Sie/Elovl4+
Genetic
Background
involves: 129P2/OlaHsd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Elovl4tm1Sie mutation (0 available); any Elovl4 mutation (6 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
reproductive system
• breed poorly
• the line failed to propagate after a few backcrosses to C57BL/6

vision/eye
• only slight differences are detected compared to wild-type retinas
• scattered areas of apoptotic photoreceptor nuclei are seen in older mice
• however, no significant reduction in electroretinogram responses are detected at 17 - 19 months of age
• rod outer segments are 20 +/- 18% shorter than in wild-type and in older mice the rod outer segments are less tightly packed
• age-related changes in the rod outer segments (irregular gaps between stacks of discs, disoriented discs, and membranous whorls) are more extensive and severe compared to wild-type mice

nervous system
• rod outer segments are 20 +/- 18% shorter than in wild-type and in older mice the rod outer segments are less tightly packed
• age-related changes in the rod outer segments (irregular gaps between stacks of discs, disoriented discs, and membranous whorls) are more extensive and severe compared to wild-type mice

Mouse Models of Human Disease
OMIM ID Ref(s)
NOT Stargardt Disease 3; STGD3 600110 J:112264


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
06/15/2016
MGI 6.04
The Jackson Laboratory