Mouse Genome Informatics
ht
    Elovl4tm1Sie/Elovl4+
involves: 129P2/OlaHsd * C57BL/6
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
       
reproductive system
• breed poorly
• the line failed to propagate after a few backcrosses to C57BL/6

vision/eye
• only slight differences are detected compared to wild-type retinas
• scattered areas of apoptotic photoreceptor nuclei are seen in older mice
• however, no significant reduction in electroretinogram responses are detected at 17 - 19 months of age
• rod outer segments are 20 +/- 18% shorter than in wild-type and in older mice the rod outer segments are less tightly packed
• age-related changes in the rod outer segments (irregular gaps between stacks of discs, disoriented discs, and membranous whorls) are more extensive and severe compared to wild-type mice

nervous system
• rod outer segments are 20 +/- 18% shorter than in wild-type and in older mice the rod outer segments are less tightly packed
• age-related changes in the rod outer segments (irregular gaps between stacks of discs, disoriented discs, and membranous whorls) are more extensive and severe compared to wild-type mice

Mouse Models of Human Disease
OMIM IDRef(s)
NOT Stargardt Disease 3; STGD3 600110 J:112264