Mouse Genome Informatics
ht
    Lrp5tm1Kry/Lrp5+
either: (involves: 129S1/Sv * 129X1/SvJ) or (involves: 129S1/Sv * 129X1/SvJ * C57BL/6J)
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
       

Abnormal osteogenesis in Lrp5tm1Kry/Lrp5+ and Lrp5tm1Kry/Lrp5tm1Kry mice

skeleton
• heterozygotes have significantly decreased bone volume compared to wild-type
• less severe than in homozygotes
• bone formation is abnormal, but bone resorption does not appear to be affected
• delay is milder in heterozygotes
• in 6-month-old mice, a 2-fold decrease in bone formation rate (BFR) is observed; similar results are seen in 2- and 4-month-old animals (88.6 um3/year vs 60.5 um3/year)

Mouse Models of Human Disease
OMIM IDRef(s)
Osteoporosis-Pseudoglioma Syndrome; OPPG 259770 J:75973