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Phenotypes Associated with This Genotype
Genotype
MGI:3664614
Allelic
Composition
Lrp5tm1Kry/Lrp5+
Genetic
Background
either: (involves: 129S1/Sv * 129X1/SvJ) or (involves: 129S1/Sv * 129X1/SvJ * C57BL/6J)
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Lrp5tm1Kry mutation (0 available); any Lrp5 mutation (38 available)
phenotype observed in females
phenotype observed in males
N normal phenotype

Abnormal osteogenesis in Lrp5tm1Kry/Lrp5+ and Lrp5tm1Kry/Lrp5tm1Kry mice

skeleton
• heterozygotes have significantly decreased bone volume compared to wild-type
• less severe than in homozygotes
• bone formation is abnormal, but bone resorption does not appear to be affected
• delay is milder in heterozygotes
• in 6-month-old mice, a 2-fold decrease in bone formation rate (BFR) is observed; similar results are seen in 2- and 4-month-old animals (88.6 um3/year vs 60.5 um3/year)

Mouse Models of Human Disease
OMIM ID Ref(s)
Osteoporosis-Pseudoglioma Syndrome; OPPG 259770 J:75973


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
05/17/2016
MGI 6.03
The Jackson Laboratory