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Phenotypes Associated with This Genotype
Genotype
MGI:3664571
Allelic
Composition		 Lrp5tm1Lex/Lrp5+
Genetic
Background		 involves: 129/Sv * C57BL/6J * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Lrp5tm1Lex mutation (0 available); any Lrp5 mutation (81 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
skeleton
decreased bone mineral density ( J:111359 )
• significantly reduced vs wild-type; present in all regions examined so values are not disproportionately reduced in animals with limb defects
abnormal trabecular bone morphology ( J:111359 )
• mice have decreased trabecular bone volume fraction (bone volume/tissue volume) compared to wild-type

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
04/16/2024
MGI 6.23 		The Jackson Laboratory