Phenotypes Associated with This Genotype

Genotype
MGI:3664430

• Allelic Composition: Ift88^Tg737Rpw/Ift88^tm1Rpw
• Genetic Background: involves: 129/Sv * FVB/N

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

renal/urinary system

kidney cyst ( J:62025 )

• identical to phenotype in Ift88^Tg737Rpw homozygotes with proximal tubule dilations and collecting duct cysts

dilated proximal convoluted tubule ( J:62025 )

• dilation of the proximal tubules

endocrine/exocrine glands

pancreatic acinar cell atrophy ( J:62025 )

• acinar cell atrophy

abnormal pancreatic duct morphology ( J:62025 )

• identical to phenotype in Ift88^Tg737Rpw homozygotes

• ductal hyperplasia

abnormal bile duct morphology ( J:62025 )

• biliary and bile duct hyperplasia

limbs/digits/tail

preaxial polydactyly ( J:62025 )

• preaxial polydactyly of both the fore- and hindlimbs

liver/biliary system

abnormal bile duct morphology ( J:62025 )

• biliary and bile duct hyperplasia

abnormal liver morphology ( J:62025 )

• identical to phenotype in Ift88^Tg737Rpw homozygotes

digestive/alimentary system

pancreatic acinar cell atrophy ( J:62025 )

• acinar cell atrophy

abnormal pancreatic duct morphology ( J:62025 )

• identical to phenotype in Ift88^Tg737Rpw homozygotes

• ductal hyperplasia

growth/size/body

kidney cyst ( J:62025 )

• identical to phenotype in Ift88^Tg737Rpw homozygotes with proximal tubule dilations and collecting duct cysts