Mouse Genome Informatics
hm
    Gpr12tm1Dgen/Gpr12tm1Dgen
B6.129P2-Gpr12tm1Dgen
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
       
growth/size
• 28% increase in the absolute amount of fat per mouse
• increased by 10% and 11% at 5 and 11 weeks of age, respectively; however, no difference in absolute food intake is detected

adipose tissue
• 28% increase in the absolute amount of fat per mouse
• 56% and 55% increase in absolute and relative (compared to brain weight) white fat
• 101% and 99% increase in absolute and relative (compared to brain weight) white fat

homeostasis/metabolism
• 21% increase in non-fasting serum glucose levels but no significant change in serum insulin levels
• decreased energy expenditure
• decrease in the respiratory exchange ratio
• 25% increase with increased HDL and LDL but not VLDL levels
• increase in hepatic triglyceride content

behavior/neurological
N
• despite differences in energy expenditure and body weight, no significant differences are seen in food or water intake or in activity level (J:111942)

liver/biliary system
• increase in hepatic triglyceride content
• 18% and 17% increase in absolute and relative (compared to brain weight) liver weight

Mouse Models of Human Disease
OMIM IDRef(s)
Obesity 601665 J:111942