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Phenotypes Associated with This Genotype
Genotype
MGI:3664276
Allelic
Composition
Gpr12tm1Dgen/Gpr12tm1Dgen
Genetic
Background
B6.129P2-Gpr12tm1Dgen
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gpr12tm1Dgen mutation (0 available); any Gpr12 mutation (5 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
growth/size/body
• increased by 10% and 11% at 5 and 11 weeks of age, respectively; however, no difference in absolute food intake is detected

adipose tissue
• 56% and 55% increase in absolute and relative (compared to brain weight) white fat
• 101% and 99% increase in absolute and relative (compared to brain weight) white fat
• 28% increase in the absolute amount of fat per mouse

homeostasis/metabolism
• 21% increase in non-fasting serum glucose levels but no significant change in serum insulin levels
• decreased energy expenditure
• decrease in the respiratory exchange ratio
• 25% increase with increased HDL and LDL but not VLDL levels
• increase in hepatic triglyceride content

behavior/neurological
N
• despite differences in energy expenditure and body weight, no significant differences are seen in food or water intake or in activity level

liver/biliary system
• increase in hepatic triglyceride content
• 18% and 17% increase in absolute and relative (compared to brain weight) liver weight

Mouse Models of Human Disease
OMIM ID Ref(s)
Obesity 601665 J:111942


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
04/26/2016
MGI 6.03
The Jackson Laboratory