Phenotypes Associated with This Genotype

Genotype
MGI:3664275

• Allelic Composition: Card9^tm1Jrld/Card9^tm1Jrld
• Genetic Background: involves: 129P2/OlaHsd

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

abnormal dendritic cell physiology ( J:111706 )

• production of Tnfa, Il6, and Il2 in response to zymosan or whole fungal cells (C. albicans) is severely impaired in bone marrow dendritic cells; however cytokine expression in response to TLR ligands is similar to wild-type

• bone marrow dendritic cells fail to produce Il10 in response to zymosan

increased susceptibility to fungal infection ( J:111706 )

• all mice die within 5 days of injection of live Candida albicans compared to about 50% mortality in wild-type mice at 12 days after infection

• 4 days after infection, macroscopic infiltration of fungal cells is seen in the kidneys and the load of fungal cells in the kidneys and liver is 100-fold higher than in wild-type mice

• however, homozygotes clear bacterial infection as well as wild-type