Analysis Tools
immune system
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• upon restimulation in vitro, T cells produce ~2-fold higher levels of Ifng compared to wild-type BALB/c controls
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• mutant T cells only show a marginal increase in production of Il-4 in the same culture
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• mutants show lower responses when infected with Leishmania major compared to control BALB/c mice; mice display up to a 30% reduction in footpad swelling especially near the end of disease progression and reduced numbers of parasites in the infected footpad
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