Phenotypes Associated with This Genotype

Genotype
MGI:3664249

• Allelic Composition: Vtcn1^tm1Mak/Vtcn1^tm1Mak
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

normal phenotype

no abnormal phenotype detected ( J:112130 )

• homozygous mice do not develop spontaneous autoimmune disease; no immune cell infiltration indicative of autoimmune disease is observed in organs of homozygotes

• total cellularity and composition of immune cells in primary and secondary lymphoid organs is not different from controls

• levels of activated T cells in the periphery is not altered compared to wild-type

• basal serum levels of immunoglobulins are not different from wild-type

• inflammatory responses in models of hypersensitivity are unaltered

• antiviral cytotoxic T lymphocyte reactions are intact in mutants as shown by responses to LCMV and influenza virus A