Phenotypes Associated with This Genotype

Genotype
MGI:3664073

• Allelic Composition: Gbx2^tm1.1Mrt/Gbx2⁺; Fgf8^tm1.4Mrt/Fgf8⁺
• Genetic Background: B6.129-Gbx2^tm1.1Mrt Fgf8^tm1.4Mrt

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

cardiovascular system

abnormal pharyngeal arch artery morphology ( J:100584 )

• ~16% of double heterozygotes exhibit PAA-related cardiovascular defects vs 0% in single Gbx2^tm1Mrt or Fgf8^tm1.4Mrt heterozygotes

• however, no incidences of a double outlet right ventricle, an overriding aorta or a retroesophageal right subclavian artery are observed

retroesophageal right subclavian artery ( J:100584 )

• 20% of double heterozygotes with cardiovascular defects display a retroesophageal right subclavian artery

right aortic arch ( J:100584 )

• 80% of double heterozygotes with cardiovascular defects exhibit a right aortic arch

craniofacial

abnormal pharyngeal arch artery morphology ( J:100584 )

• ~16% of double heterozygotes exhibit PAA-related cardiovascular defects vs 0% in single Gbx2^tm1Mrt or Fgf8^tm1.4Mrt heterozygotes

• however, no incidences of a double outlet right ventricle, an overriding aorta or a retroesophageal right subclavian artery are observed

embryo

abnormal pharyngeal arch artery morphology ( J:100584 )

• ~16% of double heterozygotes exhibit PAA-related cardiovascular defects vs 0% in single Gbx2^tm1Mrt or Fgf8^tm1.4Mrt heterozygotes

• however, no incidences of a double outlet right ventricle, an overriding aorta or a retroesophageal right subclavian artery are observed