Phenotypes Associated with This Genotype

Genotype
MGI:3664027

• Allelic Composition: Vdr^tm1Ska/Vdr^tm1Ska
• Genetic Background: involves: 129 * C57BL/6NCrlj * CBA/JNCrlj

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

abnormal response to new environment ( J:95324 )

• activity in the open field test did not decrease over time unlike in wild-type mice

abnormal startle reflex ( J:95324 )

• decreased within session habituation

impaired coordination ( J:95324 )

• fall off an accelerating or fixed speed rotating rod sooner than wild-type mice

abnormal locomotor activation ( J:95324 )

• bury fewer marbles and scatter less bedding

short stride length ( J:95324 )

• relatively normal gait but take shorter steps

decreased vertical activity ( J:95324 )

• in the holeboard and open field tests

decreased locomotor activity ( J:95324 )

• less active in a Y maze (traveling less total distance and making fewer arm entries), in a holeboard test (decreased distance traveled), in an elevated plus maze (lower distance traveled and number of closed arm entries), and in an open field test

growth/size/body

decreased body size ( J:95324 )

• shorter and lighter on a standard diet with 2 mM calcium in the water

nervous system

decreased prepulse inhibition ( J:95324 )

• at 256 ms but not 64 ms prepulse to pulse intervals

integument

alopecia ( J:95324 )

• variable severity in mice fed a standard diet with 2 mM calcium in the water