Phenotypes Associated with This Genotype

Genotype
MGI:3664025

• Allelic Composition: Tg(Myh6-Lef1)2Tfo/0
• Genetic Background: involves: C57BL/6J * FVB/N

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

cardiovascular system

decreased heart left ventricle posterior wall thickness ( J:109612 )

• left ventricular posterior wall thickness is reduced by an average of 22%

dilated heart left ventricle ( J:109612 )

dilated heart right ventricle ( J:109612 )

dilated cardiomyopathy ( J:109612 )

• ventricles are dilated with depressed contractile function, consistent with severe dilated cardiomyopathy

decreased heart ventricle muscle contractility ( J:109612 )

increased heart rate ( J:109612 )

abnormal myocardial fiber physiology ( J:109612 )

• cardiomyocytes exhibit limited ability to undergo concentric hypertrophy

muscle

dilated cardiomyopathy ( J:109612 )

• ventricles are dilated with depressed contractile function, consistent with severe dilated cardiomyopathy

decreased heart ventricle muscle contractility ( J:109612 )

abnormal myocardial fiber physiology ( J:109612 )

• cardiomyocytes exhibit limited ability to undergo concentric hypertrophy