Analysis Tools
mortality/aging
| N |
• Background Sensitivity: survival characteristics essentially normal although blood clotting defect remains
|
homeostasis/metabolism
|
• platelet aggregation fails
|
|
• absence of fibrinogen A alpha chain results in secondary loss of B beta and gamma chains in circulation but not their synthesis in the liver
• no other abnormal blood parameters
|
|
• blood unable to clot
|
cardiovascular system
 |
• bleeding into uterine cavity
|
|
• overt vaginal bleeding beginning about ten days into pregnancy
|
hemarthrosis
(
J:28436
)
|
• overt bleeding in joints develops within 2 days of birth in many mice but rarely fatal
|
|
• overt intra-abdominal and periumbilical bleeding develops within 2 days of birth in many mice
• Background Sensitivity: does not particularly affect survival
|
|
• hepatic subcapsular hematomas developing into fibrotic scars
|
|
• normal at birth
• subcutaneous bleeding develops within 2 days of birth in many mice but rarely fatal
|
reproductive system
|
|
• bleeding into uterine cavity
|
|
• overt vaginal bleeding beginning about ten days into pregnancy
|
|
|
• overt vaginal bleeding beginning about ten days into pregnancy
• about 1/3 die by day 12 of pregnancy
• bleeding into uterine cavity occurs
• embryo development arrested around day 9 to 10 of pregnancy
• death of embryos around time when trophoblasts invade and disrupt maternal vasculature
|
|
|
• homozygous females fail to give birth to live offspring
|
nervous system
|
• increased numbers of myelinating fibers after crush injury of the sciatic nerve and less proliferation of Schwann cells
• by 35 days after nerve injury, recovery is comparable to controls
|
hematopoietic system
|
• platelet aggregation fails
|
skeleton
hemarthrosis
(
J:28436
)
|
• overt bleeding in joints develops within 2 days of birth in many mice but rarely fatal
|
immune system
|
• absence of fibrinogen A alpha chain results in secondary loss of B beta and gamma chains in circulation but not their synthesis in the liver
• no other abnormal blood parameters
|
integument
|
• normal at birth
• subcutaneous bleeding develops within 2 days of birth in many mice but rarely fatal
|
liver/biliary system
|
• hepatic subcapsular hematomas developing into fibrotic scars
|
