Analysis Tools
mortality/aging
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• Background Sensitivity: 90% survive to weaning
• Background Sensitivity: only half survive beyond 70 days of age with deaths usually due to intra-abdominal bleeding
• Background Sensitivity: survival curves for females slightly better than for males
• Background Sensitivity: risk of fatal bleeding greatest between 30 and 60 days
• Background Sensitivity: mice surviving beyond 2 months continue to survive well
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homeostasis/metabolism
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• absence of fibrinogen A alpha chain results in secondary loss of B beta and gamma chains in circulation but not their synthesis in the liver
• no other abnormal blood parameters
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• exhibit distinctly larger deposits of dried blood at wound margins and scabs of wounds appear initially less stable than in controls and resumed bleeding is occasionally apparent
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• platelet aggregation fails
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• blood unable to clot
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• exhibit distinctly larger deposits of dried blood at wound margins
• scabs of wounds appear initially less stable than in controls and resumed bleeding is occasionally apparent
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cardiovascular system
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• bleeding into uterine cavity
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• overt vaginal bleeding beginning about ten days into pregnancy
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• 11% (1 of 9) show squamous stomach hemorrhage
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hemarthrosis
(
J:28436
)
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• overt bleeding in joints develops within 2 days of birth in many mice but rarely fatal
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• overt intra-abdominal and periumbilical bleeding develops within 2 days of birth in many mice
• Background Sensitivity: results in death of mice that die between weaning and 70 days of age
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• hepatic subcapsular hematomas developing into fibrotic scars
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• normal at birth
• subcutaneous bleeding develops within 2 days of birth in many mice but rarely fatal
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reproductive system
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• bleeding into uterine cavity
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• overt vaginal bleeding beginning about ten days into pregnancy
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• overt vaginal bleeding beginning about ten days into pregnancy
• about 1/3 die by day 12 of pregnancy
• bleeding into uterine cavity occurs
• embryo development arrested around day 9 to 10 of pregnancy
• death of embryos around time when trophoblasts invade and disrupt maternal vasculature
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• homozygous females fail to give birth to live offspring
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nervous system
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• increased numbers of myelinating fibers after crush injury of the sciatic nerve and less proliferation of Schwann cells
• by 35 days after nerve injury, recovery is comparable to controls
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hematopoietic system
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• platelet aggregation fails
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skeleton
hemarthrosis
(
J:28436
)
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• overt bleeding in joints develops within 2 days of birth in many mice but rarely fatal
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endocrine/exocrine glands
pancreas cyst
(
J:36591
)
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• 11% (1 of 9) show pancreatic cyst
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liver/biliary system
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• hepatic subcapsular hematomas developing into fibrotic scars
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• 33% (3 of 9) show necrotic liver foci
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immune system
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• absence of fibrinogen A alpha chain results in secondary loss of B beta and gamma chains in circulation but not their synthesis in the liver
• no other abnormal blood parameters
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digestive/alimentary system
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• 11% (1 of 9) show squamous stomach hemorrhage
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integument
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• normal at birth
• subcutaneous bleeding develops within 2 days of birth in many mice but rarely fatal
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growth/size/body
pancreas cyst
(
J:36591
)
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• 11% (1 of 9) show pancreatic cyst
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