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Phenotypes Associated with This Genotype
Genotype
MGI:3663621
Allelic
Composition
Tg(APP695)3Dbo/0
Genetic
Background
involves: C3H/HeJ * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(APP695)3Dbo mutation (3 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
nervous system
N
• no immunoreactive amyloid beta deposits found in cortex or hippocampus from 12 month old mice as compared to double transgenic mice: Tg(APP695)3Dbo/0, Tg(PSEN1)5Dbo/0
• amyloid beta deposits observed in cortex and hippocampus of 18 and 20 month old mice (J:43788)
• ratio of amyloid beta peptide 40:42 is 3:1 (J:87691)

homeostasis/metabolism
• amyloid beta deposits observed in cortex and hippocampus of 18 and 20 month old mice (J:43788)
• ratio of amyloid beta peptide 40:42 is 3:1 (J:87691)

Mouse Models of Human Disease
DO ID OMIM ID(s) Ref(s)
Alzheimer's disease DOID:10652 OMIM:104300
OMIM:502500
OMIM:604154
OMIM:608907
J:87691


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
09/12/2017
MGI 6.10
The Jackson Laboratory