Phenotypes Associated with This Genotype

Genotype
MGI:3663493

• Allelic Composition: Lepr^tm1.1Chua/Lepr^tm1.1Chua; Tg(Nr5a1-cre)2Lowl/0; Tg(Pomc1-cre)16Lowl/0
• Genetic Background: involves: 129 * C57BL/6J * FVB

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

adipose tissue

increased total body fat amount ( J:105327 )

• increase in fat mass

abnormal fat pad morphology ( J:105327 )

• size of fat pads (perigonadal, perirenal, and mesenteric) is increased

abnormal gonadal fat pad morphology ( J:105327 )

abnormal mesenteric fat pad morphology ( J:105327 )

abnormal renal fat pad morphology ( J:105327 )

growth/size/body

obese ( J:105327 )

• weigh significantly more than mice lacking Lepr only in SF1 neurons or POM1 neurons

homeostasis/metabolism

increased circulating leptin level ( J:105327 )