Phenotypes for Emx1 Htr2a MGI:3663441 MGI Mouse

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Phenotypes Associated with This Genotype

Allelic Composition	Emx1^tm1(cre)Ito/Emx1⁺ Htr2a^tm1Grch/Htr2a^tm2Grch
Genetic Background	129S6.Cg-Htr2a^tm1Grch Htr2a^tm2Grch Emx1^tm1(cre)Ito

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Emx1^tm1(cre)Ito mutation (1 available); any Emx1 mutation (31 available)
Htr2a^tm1Grch mutation (0 available); any Htr2a mutation (48 available)
Htr2a^tm2Grch mutation (0 available); any Htr2a mutation (48 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

behavior/neurological

behavior/neurological phenotype ( J:110958 )

• selective restoration of 5HT2AR signaling to the cortex normalized conflict anxiety behaviors

• exhibited wild-type levels of anxiety-like behavior as measured by the open field test, dark-light choice test, and novelty suppressed feeding paradigm

• depression-related paradigms, such as the forced swim test and tail suspension test, were unchanged compared to un-restored homozygous null litter mate

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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