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Phenotypes Associated with This Genotype
Genotype
MGI:3663263
Allelic
Composition		 Otx2tm1Sla/Otx2+
Genetic
Background		 involves: 129S1/Sv * 129X1/SvJ * CD-1
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Otx2tm1Sla mutation (0 available); any Otx2 mutation (50 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
preweaning lethality, incomplete penetrance ( J:30828 )
• slightly lower numbers of heterozygotes are obtained at 3 weeks of age than expected

nervous system
open neural tube ( J:30828 )
• open at the forebrain and midbrain levels

embryo
open neural tube ( J:30828 )
• open at the forebrain and midbrain levels

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
03/25/2025
MGI 6.24 		The Jackson Laboratory