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Phenotypes Associated with This Genotype
Genotype
MGI:3663129
Allelic
Composition
Fgf14tm1Dor/Fgf14tm1Dor
Genetic
Background
B6.129S6-Fgf14tm1Dor
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Fgf14tm1Dor mutation (0 available); any Fgf14 mutation (30 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
growth/size/body
• Background Sensitivity: growth of mice on a B6 background is normal through weaning although adult weight is 15% smaller than controls

behavior/neurological
• mice exhibit impaired acquisition performance during place trials in both escape path length and latency to find the submerged platform
• mice also show impaired acquisition performance when they are restested in the water maze and required to learn another submerged platform location in the presence of different spatial cues
• increasing the memory load for the water navigation task results in performance deficits in mice that are not seen with less challenging memory demands
• however, mice exhibit normal conditioned fear and passive avoidance performance
• nonepileptic forelimb clonic spasms and hyperextension of hindlimbs - paroxysmal dyskinesia
• retract hind feet and clench digits when suspended by the tail
• ataxic gait (J:77806)
(J:134733)
• poor performance on both a ledge and a platform test
• poor performance on an accelerating rotarod test and no improvement with practice (J:77806)
• mice exhibit impaired performance on the platform and inverted screen and on the constant speed and accelerating rotarod (J:134733)
• inferior ability to climb on an inclined screen (J:77806)
• inability to stay on in an inverted screen test (J:77806)
• mice show reduced forelimb strength in gripping a bar (J:134733)
• widened stance
• slow to initiate movement although overall activity levels are normal
• mice are hyperactive, showing more ambulations than wild-type mice during a 1 hour test period
• shuffling footprint pattern

nervous system
• hyperactive response to cocaine, amphetamine, and specific dopamine receptor agonists is reduced
• impaired dopamine 2 receptor-mediated signalling
• both the striatonigral and striatopallial nerve pathways function abnormally although the striatopallial pathway is affected more
• mice exhibit impaired theta burst induced LTP
• however, mice show normal hippocampus, parahippocampal region and amygdala anatomy

Mouse Models of Human Disease
DO ID OMIM ID(s) Ref(s)
spinocerebellar ataxia type 27 DOID:0050976 OMIM:609307
J:134733


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
12/05/2017
MGI 6.11
The Jackson Laboratory