Phenotypes Associated with This Genotype

Genotype
MGI:3663128

• Allelic Composition: Fgf14^tm1Dor/Fgf14^tm1Dor
• Genetic Background: 129S6/SvEvTac-Fgf14^tm1Dor

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

growth/size/body

slow postnatal weight gain ( J:77806 )

• Background Sensitivity: growth lags behind controls during the 3rd and 4th weeks of life but parallels growth in controls at all other times

behavior/neurological

increased susceptibility to pharmacologically induced seizures ( J:77806 )

abnormal motor capabilities/coordination/movement ( J:77806 )

• nonepileptic forelimb clonic spasms and hyperextension of hindlimbs - paroxysmal dyskinesia

limb grasping ( J:77806 )

• retract hind feet and clench digits when suspended by the tail

ataxia ( J:77806 )

• ataxic gait

impaired balance ( J:77806 )

• poor performance on both a ledge and a platform test

impaired coordination ( J:77806 )

• poor performance on an accelerating rotarod test and no improvement with practice

decreased grip strength ( J:77806 )

• inferior ability to climb on an inclined screen

• inability to stay on in an inverted screen test

abnormal posture ( J:77806 )

• widened stance

abnormal locomotor activation ( J:77806 )

• slow to initiate movement although overall activity levels are normal

abnormal gait ( J:77806 )

• shuffling footprint pattern

nervous system

abnormal nervous system physiology ( J:77806 )

• hyperactive response to cocaine, amphetamine, and specific dopamine receptor agonists is reduced

• impaired dopamine 2 receptor-mediated signalling

• both the striatonigral and striatopallial nerve pathways function abnormally although the striatopallial pathway is affected more

increased susceptibility to pharmacologically induced seizures ( J:77806 )