Phenotypes Associated with This Genotype

Genotype
MGI:3663107

• Allelic Composition: Fgf8^tm1.4Mrt/Fgf8⁺; Fgf17^tm1Dor/Fgf17^tm1Dor
• Genetic Background: involves: 129P2/OlaHsd * 129S6/SvEvTac

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

nervous system

decreased inferior colliculus size ( J:61429 )

• tissue losses in inferior colliculus

abnormal Purkinje cell morphology ( J:61429 )

• Purkinje cell migration begins earlier than normal

abnormal cerebellum vermis morphology ( J:61429 )

• overall size of vermis about 76% of control size but hemispheres normal

• decreased cell proliferation in vermis by E11.5

• neuroepithelium thinner than normal

abnormal cerebellum anterior vermis morphology ( J:61429 )

• lobe III of the vermis is lost by age 2 days and in adults

behavior/neurological

abnormal gait ( J:61429 )

• asymmetrical gait seen in about 20% of mice