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Phenotypes Associated with This Genotype
Genotype
MGI:3663041
Allelic
Composition		 Tg(Ins2-Fas*I246N)1Ach/0
Tg(Ins2-Fasl)24Ach/0
Genetic
Background		 NOD-Tg(Ins2-Fas*I246N)1Ach Tg(Ins2-Fasl)24Ach
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(Ins2-Fas*I246N)1Ach mutation (1 available)
Tg(Ins2-Fasl)24Ach mutation (1 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
decreased susceptibility to autoimmune diabetes ( J:81416 )
• double transgenics show slower onset of diabetes compared to NOD-Tg(Ins2-Fasl)24Ach single transgenics

Mouse Models of Human Disease
 DO ID OMIM ID(s) Ref(s)
type 1 diabetes mellitus DOID:9744 OMIM:222100
 J:81416

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
04/30/2024
MGI 6.23 		The Jackson Laboratory