Phenotypes for Foxd3 MGI:3662915 MGI Mouse

• at E6.5 the anterior visceral endoderm remains at the distal tip of the embryo unlike in wild-type mice where this tissue has moved anteriorly

abnormal developmental patterning ( J:79491 )

failure to gastrulate ( J:79491 )

• gastrulation does not occur

• by E7.5 the entire distal end of the embryo is severely truncated

• expression of extraembryonic cell markers is expanded distally

• transplanted E6.5 epiblasts fail to generate teratocarcinomas suggesting loss of the pluripotent cells

• decreased cell proliferation at E6.5

small embryonic epiblast ( J:79491 )

• small at E6.5

absent mesoderm ( J:79491 )

• at E6.5 expression analysis indicates that mesodermal cells are not formed

• at E6.5, finger-like protrusions of cells resembling extraembryonic endoderm are found at the distal tip of the embryo

• at E6.5 the anterior visceral endoderm remains at the distal tip of the embryo unlike in wild-type mice where this tissue has moved anteriorly

abnormal cell proliferation ( J:79491 )

• unable to generate homozygous ES cells either from blastocysts or by retargeting heterozygous ES cells

• transplanted E6.5 epiblasts fail to generate teratocarcinomas suggesting loss of the pluripotent cells

• decreased cell proliferation at E6.5

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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