Mouse Genome Informatics
hm
    Fggtm1Fjc/Fggtm1Fjc
involves: 129S1/Sv * 129X1/SvJ * C57BL/6
Key:
phenotype observed in females
phenotype observed in males
N normal phenotype
cardiovascular system
• ~25% of newborn homozygotes suffer from primarily abdominal hemorrhages, although hemorrhages around the cranial, neck, and nasal areas are also observed
• however, many homozygotes are able to resolve the bleeding and recover
• ~25% of newborn homozygotes suffer from primarily abdominal hemorrhages
• pregnant female homozygotes consistently present with various degrees of vaginal bleeding beginning at E7
• excessive maternal bleeding is detected at the implantation site in the uterus as early as E6

homeostasis/metabolism
• homozygotes exhibit significantly delayed thrombin-induced plasma clot times (>17 min) relative to wild-type mice (35.5 3.5 sec)

reproductive system
• pregnant female homozygotes consistently present with various degrees of vaginal bleeding beginning at E7
• excessive maternal bleeding is detected at the implantation site in the uterus as early as E6
• at E6, embryos in the uteri of pregnant female homozygotes show severe bleeding in regions around the ectoplacental cone, resulting in blood-filled lacunae at E8 to E9
• by E9 large areas of bleeding initiate the disruption of the placenta and yolk sac from the endometrium
• pregnant female homozygotes undergo spontaneous abortion, with resulting maternal death at E9.75 through excessive bleeding
• a minimal dosage schedule of 10 mg of fibrinogen at E8.5 and E17.5 rescues pregnancy and results in successful vaginal deliveries

embryogenesis
• at E9.75, embryos obtained from female pregnant homozygotes are significantly smaller and show bleeding in the egg cylinder cavity
• at E9.75, placental detachment occurs from the implantation site
• female homozygotes exhibit abnormal development of fetal-maternal vascular communication and stabilization of embryo implantation
• afibrinogenemic pregnant females show detachment of the fibrinoid layer from the decidua and disruption of sinusoids of the labyrinths with severe hemorrhage along the planes of placental-decidual attachment
• at E9, embryos obtained from pregnant female homozygotes display a smaller placenta
• at E9.75, embryos obtained from female pregnant homozygotes display a significantly smaller yolk sac

growth/size/body
• at E9.75, embryos obtained from female pregnant homozygotes are significantly smaller and show bleeding in the egg cylinder cavity

respiratory system
N
• in response to bleomycin-induced acute lung injury, homozygotes show no significant differences in the deposition of interstitial collagen and pulmonary fibrotic lesions at 7 and 14 days after intratracheal administration of bleomycin relative to wild type mice

Mouse Models of Human Disease
OMIM IDRef(s)
Afibrinogenemia, Congenital 202400 J:75302