Phenotypes Associated with This Genotype

Genotype
MGI:3662676

• Allelic Composition: Tg(Igh-6-Cd86)1Akab/0
• Genetic Background: involves: FVB

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

hematopoietic system

decreased B cell number ( J:44271 )

• a defect in B cell maturation similar to that in Tg(Igh-6-Cd80)1Gjf mice is observed

• 3 week old transgenics have fewer B cells than wild-type mice; percentage of B cells in the spleens of young wild-type is 54% vs 25% in transgenics

• adult mice have comparable numbers of B cells in the spleens

abnormal CD4-positive, alpha-beta T cell physiology ( J:44271 )

• transgene expressing T cells can be activated by anti-CD3 alone, whereas wild-type T cells require presence of costimulatory signals for activation

immune system

decreased B cell number ( J:44271 )

• a defect in B cell maturation similar to that in Tg(Igh-6-Cd80)1Gjf mice is observed

• 3 week old transgenics have fewer B cells than wild-type mice; percentage of B cells in the spleens of young wild-type is 54% vs 25% in transgenics

• adult mice have comparable numbers of B cells in the spleens

abnormal CD4-positive, alpha-beta T cell physiology ( J:44271 )

• transgene expressing T cells can be activated by anti-CD3 alone, whereas wild-type T cells require presence of costimulatory signals for activation