Phenotypes Associated with This Genotype

Genotype
MGI:3662675

• Allelic Composition: Cd80^tm1Shr/Cd80^tm1Shr; Cd86^tm2Shr/Cd86^tm2Shr
• Genetic Background: involves: 129S4/SvJae * BALB/c

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

hematopoietic system

abnormal T cell number ( J:112266 )

• mice have increased CD4/CD8 ratios in the spleen (4.1 vs 2.2 in controls) and in lymph nodes (6.6 vs 2.8 in controls), reciprocal to the decreased ratios seen in transgenic Cd86 or Cd80 mice

decreased double-positive T cell number ( J:112266 )

• ther are fewer double positive cells (74.3%) compared to controls (83.8%) and higher CD4+ cell numbers (17.2% vs 10.5%)

immune system

abnormal T cell number ( J:112266 )

• mice have increased CD4/CD8 ratios in the spleen (4.1 vs 2.2 in controls) and in lymph nodes (6.6 vs 2.8 in controls), reciprocal to the decreased ratios seen in transgenic Cd86 or Cd80 mice

decreased double-positive T cell number ( J:112266 )

• ther are fewer double positive cells (74.3%) compared to controls (83.8%) and higher CD4+ cell numbers (17.2% vs 10.5%)