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Phenotypes Associated with This Genotype
Genotype
MGI:3662672
Allelic
Composition		 Cd28tm1Mak/Cd28tm1Mak
Tg(H2-K-Cd86)7All/0
Genetic
Background		 involves: BALB/c * C57BL/6 * CBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cd28tm1Mak mutation (13 available); any Cd28 mutation (51 available)
Tg(H2-K-Cd86)7All mutation (0 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
hematopoietic system
abnormal T cell differentiation ( J:112266 )
• compared to wild-type Cd28 transgenic mice Cd28-deficient mice show no lymphocyte expansion or increase in CD8+ T cell population

immune system
abnormal T cell differentiation ( J:112266 )
• compared to wild-type Cd28 transgenic mice Cd28-deficient mice show no lymphocyte expansion or increase in CD8+ T cell population

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
03/18/2025
MGI 6.24 		The Jackson Laboratory