Phenotypes Associated with This Genotype

Genotype
MGI:3662668

• Allelic Composition: Ptk6^tm1Aty/Ptk6^tm1Aty
• Genetic Background: either: B6.Cg-Ptk6^tm1Aty or (involves: 129S1/Sv * 129X1/SvJ * C57BL/6J)

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

digestive/alimentary system

abnormal small intestine morphology ( J:110331 )

• increase in villus epithelial cell proliferation and expansion of the proliferative zone compared to wild-type; however no significant difference in intestinal absorption is detected on standard or high fat diets

• enterocytes are only detected in the upper half of the villus unlike in wild-type mice where these cells are also found in the lower half of the villus

abnormal ileum morphology ( J:110331 )

• increase in villus length in the distal ileum

abnormal jejunum morphology ( J:110331 )

• increase in villus length