Phenotypes Associated with This Genotype

Genotype
MGI:3662665

• Allelic Composition: \Tg(H2-K-Cd86)7All/0
• Genetic Background: involves: BALB/c * C57BL/6 * CBA

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

hematopoietic system

spleen hyperplasia ( J:112266 )

• number of splenocytes is increased by >200-fold

• on a (BALB/c x C57BL/6)F1 background peripheral lymphocyte proliferation is greater with splenocyte numbers compared to a coisogenic B6 background

increased splenocyte number ( J:112266 )

• number of splenocytes is increased by >200-fold

immune system

spleen hyperplasia ( J:112266 )

• number of splenocytes is increased by >200-fold

• on a (BALB/c x C57BL/6)F1 background peripheral lymphocyte proliferation is greater with splenocyte numbers compared to a coisogenic B6 background

increased splenocyte number ( J:112266 )

• number of splenocytes is increased by >200-fold

lymph node hyperplasia ( J:112266 )

• in peripheral lymph nodes, there is a significant lymphocyte expansion with lymph node cells increased >10-fold over littermate controls

• Background Sensitivity: on a (BALB/c x C57BL/6)F1 background peripheral lymphocyte proliferation is greater compared to a coisogenic B6 background

growth/size/body

spleen hyperplasia ( J:112266 )

• number of splenocytes is increased by >200-fold

• on a (BALB/c x C57BL/6)F1 background peripheral lymphocyte proliferation is greater with splenocyte numbers compared to a coisogenic B6 background