Phenotypes for Tg(H2-K-Cd86)7All MGI:3662662 MGI Mouse

decreased B cell number ( J:112266 )

• there is a decreased proportion of B cells in the spleens compared to controls

decreased CD4-positive, alpha-beta T cell number ( J:112266 )

• a similarly small but significant decrease in percentage of single positive CD4 thymocytes is observed

• in the spleen there is a lower percentage of CD4+ T cells that is more evident than in the thymus

increased T cell number ( J:112266 )

• in the spleens there is an increase in T cell number

increased CD8-positive, alpha-beta T cell number ( J:112266 )

• a small but significant increase in percentage of single-positive CD8 thymocytes is seen compared to controls

• in the spleen there is a higher percentage of CD8+ T cells that is more evident than in the thymus

lymph node hyperplasia ( J:112266 )

• in peripheral lymph nodes, there is a significant lymphocyte expansion with lymph node cells increased >6-fold over littermate controls

• Background Sensitivity: on a B6 congenic background peripheral lymphocyte proliferation is lower compared to that on a (BALB/c x C57BL/6)F1 background

lymphoid hyperplasia ( J:112266 )

• expression of the Cd86 transgene results in hyperplasia of peripheral lymphoid organs

abnormal inflammatory response ( J:112266 )

• there is extensive lymphoid infiltration of other organs including the lungs