Phenotypes Associated with This Genotype

Genotype
MGI:3662648

• Allelic Composition: Tg(H2-K-Cd86)27All/0
• Genetic Background: involves: C57BL/6J * CBA

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

hematopoietic system

abnormal B cell differentiation ( J:112475 )

• B cells are slightly larger and express higher levels of MHC class II than wild-type

• proportion of pre/pro B cells and immature/mature B cells is drastically reduced in bone marrow in transgenic mice

decreased B cell number ( J:112475 )

• mice expressing the transgene at moderate levels show a substantial reduction in B lymphocytes in all peripheral tissues

immune system

abnormal B cell differentiation ( J:112475 )

• B cells are slightly larger and express higher levels of MHC class II than wild-type

• proportion of pre/pro B cells and immature/mature B cells is drastically reduced in bone marrow in transgenic mice

decreased B cell number ( J:112475 )

• mice expressing the transgene at moderate levels show a substantial reduction in B lymphocytes in all peripheral tissues