Phenotypes Associated with This Genotype

Genotype
MGI:3662635

• Allelic Composition: Tcrb^tm1Mom/Tcrb^tm1Mom; Tg(H2-K-Cd86)7All/0
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * CBA

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

hematopoietic system

hematopoietic system phenotype ( J:112475 )

N • mice have same numbers of B cells in spleen and lymph nodes as control littermates

abnormal B cell morphology ( J:112475 )

• transgenic B cells increase in size and show upregulated MHC class II when mice are injected with T cells

abnormal B cell differentiation ( J:112475 )

• mice show a substantial decrease in B220+ cells in bone marrow when mice receive nontransgenic T cells

decreased B cell number ( J:112475 )

• when syngeneic wild-type T cells are transferred into Tcrb-deficient transgenic hosts, after 3 weeks the number of B cells in peripheral lymphoid tissues is decreased by ~50% compared with Tcrb-deficient mice not injected with T cells

immune system

abnormal B cell morphology ( J:112475 )

• transgenic B cells increase in size and show upregulated MHC class II when mice are injected with T cells

abnormal B cell differentiation ( J:112475 )

• mice show a substantial decrease in B220+ cells in bone marrow when mice receive nontransgenic T cells

decreased B cell number ( J:112475 )

• when syngeneic wild-type T cells are transferred into Tcrb-deficient transgenic hosts, after 3 weeks the number of B cells in peripheral lymphoid tissues is decreased by ~50% compared with Tcrb-deficient mice not injected with T cells