Phenotypes Associated with This Genotype

Genotype
MGI:3662634

• Allelic Composition: Tg(H2-K-Cd86)7All/0
• Genetic Background: involves: C57BL/6J * CBA

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

hematopoietic system

abnormal B cell differentiation ( J:112475 )

• proportion of pre/pro B cells and immature/mature B cells is low in bone marrow in transgenic mice

• B cells are slightly larger than wild-type

decreased B cell number ( J:112475 )

• some mice expressing transgene at high levels show substantial reduction in B lymphocytes in all peripheral tissues; some mice exhibit a severe reduction in number in spleen with an increase in number the lymph nodes

increased CD4-positive, alpha-beta T cell number ( J:112475 )

• numbers of CD4+ T cells are increased in the spleen but not in lymph nodes of mice; an increased fraction of and T cells are CD44^hi

increased CD8-positive, alpha-beta T cell number ( J:112475 )

• numbers of CD8+ T cells are increased in the spleen but not in lymph nodes of mice; an increased fraction of CD8+ cells are CD44^hi

immune system

abnormal B cell differentiation ( J:112475 )

• proportion of pre/pro B cells and immature/mature B cells is low in bone marrow in transgenic mice

• B cells are slightly larger than wild-type

decreased B cell number ( J:112475 )

• some mice expressing transgene at high levels show substantial reduction in B lymphocytes in all peripheral tissues; some mice exhibit a severe reduction in number in spleen with an increase in number the lymph nodes

increased CD4-positive, alpha-beta T cell number ( J:112475 )

• numbers of CD4+ T cells are increased in the spleen but not in lymph nodes of mice; an increased fraction of and T cells are CD44^hi

increased CD8-positive, alpha-beta T cell number ( J:112475 )

• numbers of CD8+ T cells are increased in the spleen but not in lymph nodes of mice; an increased fraction of CD8+ cells are CD44^hi