Phenotypes Associated with This Genotype

Genotype
MGI:3656072

• Allelic Composition: Flt3l^tm1Imx/Flt3l^tm1Imx
• Genetic Background: C57BL/6-Flt3l^tm1Imx

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

increased IgM level ( J:62536 )

• other immune globulins and cell surface IgM are all normal

abnormal immune system cell morphology ( J:62536 )

impaired myelopoiesis ( J:62536 )

• reduced numbers of immature myeloid cells in bone marrow

abnormal leukocyte morphology ( J:62536 )

abnormal immature B cell morphology ( J:62536 )

• in bone marrow

decreased pro-B cell number ( J:62536 , J:79569 )

• 75-90% reduction in B cell precursor cells, both frequency and absolute numbers (J:62536)

• preferentially reduced in number (J:79569)

increased neutrophil cell number ( J:62536 )

• neutrophiles increased by about 20%

decreased leukocyte cell number ( J:62536 )

• WBC reduced 45% in peripheral blood

decreased plasmacytoid dendritic cell number ( J:62536 , J:89868 )

• lymphoid related dendritic cells are reduced in the spleen, thymus, and lymph nodes (J:62536)

• reduced in numbers in parenchymal organs such as the heart but not in skin (J:89868)

• less extensive dendrites on all dendritic cells (J:89868)

decreased lymphocyte cell number ( J:62536 )

• proportion of lymphocytes reduced significantly by about 76%

decreased double-negative T cell number ( J:79569 )

• pro-T cells are reduced up to 72% in the thymus whereas more mature pre-T cells are present in more normal numbers

decreased B cell number ( J:79569 )

• slight but significant reduction in peripheral B cell numbers

decreased pre-B cell number ( J:79569 )

• preferentially reduced in number

decreased NK cell number ( J:62536 )

• numbers of natural killer cells in the spleen are dramatically reduced

abnormal dendritic cell morphology ( J:62536 , J:89868 )

decreased myeloid dendritic cell number ( J:62536 , J:89868 )

• myeloid related dendritic cells reduced in spleen, thymus, and lymph nodes (J:62536)

• reduced in numbers in parenchymal organs such as the heart but not in skin (J:89868)

• less extensive dendrites on all dendritic cells (J:89868)

abnormal immune system organ morphology ( J:62536 )

spleen hypoplasia ( J:62536 )

• reduced by 30%

• both T and B cell numbers are reduced but the ratio of T to B cells is unchanged

• organ architecture remains normal

lymph node hypoplasia ( J:62536 )

• reduced by 35%

• both T and B cell numbers are reduced but the ratio of T to B cells is unchanged

• organ architecture remains normal

increased length of allograft survival ( J:89868 )

• allographs of hearts to BALB/c recipients show prolonged survival but not skin grafts

hematopoietic system

abnormal common myeloid progenitor cell morphology ( J:62536 )

• reduced absolute number of myeloid lineage precursors in bone marrow

impaired myelopoiesis ( J:62536 )

• reduced numbers of immature myeloid cells in bone marrow

decreased bone marrow cell number ( J:62536 )

• cellularity reduced by 27%

abnormal common lymphocyte progenitor cell morphology ( J:79569 )

• earliest common lymphoid cell precursors in bone marrow are reduced 10 fold

decreased hematopoietic stem cell number ( J:62536 )

• multipotent precursors reduced by 39% in bone marrow

abnormal leukocyte morphology ( J:62536 )

abnormal immature B cell morphology ( J:62536 )

• in bone marrow

decreased pro-B cell number ( J:62536 , J:79569 )

• 75-90% reduction in B cell precursor cells, both frequency and absolute numbers (J:62536)

• preferentially reduced in number (J:79569)

increased neutrophil cell number ( J:62536 )

• neutrophiles increased by about 20%

decreased leukocyte cell number ( J:62536 )

• WBC reduced 45% in peripheral blood

decreased plasmacytoid dendritic cell number ( J:62536 , J:89868 )

• lymphoid related dendritic cells are reduced in the spleen, thymus, and lymph nodes (J:62536)

• reduced in numbers in parenchymal organs such as the heart but not in skin (J:89868)

• less extensive dendrites on all dendritic cells (J:89868)

decreased lymphocyte cell number ( J:62536 )

• proportion of lymphocytes reduced significantly by about 76%

decreased double-negative T cell number ( J:79569 )

• pro-T cells are reduced up to 72% in the thymus whereas more mature pre-T cells are present in more normal numbers

decreased B cell number ( J:79569 )

• slight but significant reduction in peripheral B cell numbers

decreased pre-B cell number ( J:79569 )

• preferentially reduced in number

decreased NK cell number ( J:62536 )

• numbers of natural killer cells in the spleen are dramatically reduced

abnormal dendritic cell morphology ( J:62536 , J:89868 )

decreased myeloid dendritic cell number ( J:62536 , J:89868 )

• myeloid related dendritic cells reduced in spleen, thymus, and lymph nodes (J:62536)

• reduced in numbers in parenchymal organs such as the heart but not in skin (J:89868)

• less extensive dendrites on all dendritic cells (J:89868)

spleen hypoplasia ( J:62536 )

• reduced by 30%

• both T and B cell numbers are reduced but the ratio of T to B cells is unchanged

• organ architecture remains normal

increased IgM level ( J:62536 )

• other immune globulins and cell surface IgM are all normal