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Phenotypes Associated with This Genotype
Genotype
MGI:3655859
Allelic
Composition
Acadvltm1Vje/Acadvltm1Vje
Genetic
Background
involves: 129/Sv * Black Swiss * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Acadvltm1Vje mutation (0 available); any Acadvl mutation (2 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• exhibit a decrease in survival after short exposure to cold and fasting unlike wild-type (J:106714)
• exhibit a decrease in survival after short exposure to cold and fasting unlike wild-type (J:106714)

adipose tissue
• brown adipose tissue shows elevated levels of the uncoupling protein isoforms and peroxisome proliferators-activated receptor-alpha (J:106714)
• brown adipose tissue shows elevated levels of the uncoupling protein isoforms and peroxisome proliferators-activated receptor-alpha (J:106714)
• brown adipose tissue shows increased oxygen consumption, attributed to uncoupled respiration in the absence of stress (J:106714)
• brown adipose tissue shows increased oxygen consumption, attributed to uncoupled respiration in the absence of stress (J:106714)

cardiovascular system
• exhibit microvesicular fat infiltration of cardiomyocytes (cardiac lipidosis) after combined stresses of fasting and cold that are not observed in wild-type (J:106714)
• exhibit microvesicular fat infiltration of cardiomyocytes (cardiac lipidosis) after combined stresses of fasting and cold that are not observed in wild-type (J:106714)
• develop severe bradycardia with the combination of fasting and cold stress (J:106714)
• glucose administration in conjunction with rewarming or rewarming alone (but not glucose alone) reverse the bradycardia and rescue the mice (J:106714)
• develop severe bradycardia with the combination of fasting and cold stress (J:106714)
• glucose administration in conjunction with rewarming or rewarming alone (but not glucose alone) reverse the bradycardia and rescue the mice (J:106714)

cellular
• exhibit abnormal mitochondrial bioenergetics of brown adipose tissue after the combination of fasting and cold stresses, as evident by altered mitochondrial oxygen consumption and terminally uncoupled mitochondria (J:106714)
• exhibit abnormal mitochondrial bioenergetics of brown adipose tissue after the combination of fasting and cold stresses, as evident by altered mitochondrial oxygen consumption and terminally uncoupled mitochondria (J:106714)

homeostasis/metabolism
• develop decreased body temperature during the combined stresses of fasting and cold (J:106714)
• develop decreased body temperature during the combined stresses of fasting and cold (J:106714)
• upon exposure to stresses of fasting alone or cold alone, mutants are able to maintain normal blood glucose levels, however levels of C16 and C18 acylcarnitines are elevated (J:106714)
• upon exposure to stresses of fasting alone or cold alone, mutants are able to maintain normal blood glucose levels, however levels of C16 and C18 acylcarnitines are elevated (J:106714)
• develop low blood sugar levels during the combined stresses of fasting and cold (J:106714)
• develop low blood sugar levels during the combined stresses of fasting and cold (J:106714)
• the decrease in liver glycogen levels during the combined stresses of fasting and cold is more pronounced in homozygotes than controls (J:106714)
• the decrease in liver glycogen levels during the combined stresses of fasting and cold is more pronounced in homozygotes than controls (J:106714)

liver/biliary system
• exhibit severe macrovesicular hepatic steatosis after the combined stresses of fasting and cold whereas only see minimal fat infiltration in wild-type livers (J:106714)
• exhibit severe macrovesicular hepatic steatosis after the combined stresses of fasting and cold whereas only see minimal fat infiltration in wild-type livers (J:106714)

muscle
• exhibit microvesicular fat infiltration of cardiomyocytes (cardiac lipidosis) after combined stresses of fasting and cold that are not observed in wild-type (J:106714)
• exhibit microvesicular fat infiltration of cardiomyocytes (cardiac lipidosis) after combined stresses of fasting and cold that are not observed in wild-type (J:106714)


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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
02/02/2016
MGI 6.02
The Jackson Laboratory