Phenotypes Associated with This Genotype

Genotype
MGI:3655840

• Allelic Composition: Lpl^tm1Ijg/Lpl^tm1Ijg; Tg(Myh6-cre)2182Mds/0
• Genetic Background: involves: FVB/N

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

Increase in interstitial and perivascular collagen in Lpl^tm1Ijg/Lpl^tm1Ijg Tg(Myh6-cre)2182Mds/0 hearts

mortality/aging

increased susceptibility to induced morbidity/mortality ( J:110484 )

• all mutants subjected to abdominal aortic constriction (AbAC) die within 2 days whereas controls survive

cardiovascular system

cardiac fibrosis ( J:110484 )

• hearts from non-stressed 4-5 month old males, but not females, show increased fibrosis as indicated by Trichrome staining; fibrosis is both interstitial and perivascular

cardiac interstitial fibrosis ( J:110484 )

• seen in non-stressed 4-5 month old males

abnormal cardiovascular system physiology ( J:110484 )

• hearts from both 4-5 month old males and females exhibit higher rates of glycolysis and glucose oxidation

• palmitate oxidation rates in male and female hearts are reduced by 52 and 40%, respectively, indicating reduction in fatty acid utilization

• heart uptake of VLDL triglycerides is decreased by 49% and uptake of palmitate, a free fatty acid, is increased by 56% in females

• male, but not female, hearts show a reduction in cardiac power

increased cardiac muscle cell glucose uptake ( J:110484 )

• myocardial basal glucose uptake is increased 5.5-fold

decreased heart left ventricle muscle contractility ( J:110484 )

• 6-month old mutants exhibit an increase in left ventricular systolic dimension and a decrease in fractional shortening under basal conditions

increased left ventricle diastolic pressure ( J:110484 )

• mutants subjected to abdominal aortic constriction exhibit an increase in left ventricular end diastolic pressure that is not observed in banded controls

increased left ventricle systolic pressure ( J:110484 )

• mutants subjected to abdominal aortic constriction exhibit a greater increase in left ventricular systolic pressure than banded controls

homeostasis/metabolism

increased circulating triglyceride level ( J:110484 )

• 4 month old females show elevated plasma triglyceride levels, however plasma cholesterol, free fatty acid, and glucose levels are normal

abnormal glucose homeostasis ( J:110484 )

• hearts from both 4-5 month old males and females exhibit higher rates of glycolysis and glucose oxidation

muscle

increased cardiac muscle cell glucose uptake ( J:110484 )

• myocardial basal glucose uptake is increased 5.5-fold

decreased heart left ventricle muscle contractility ( J:110484 )

• 6-month old mutants exhibit an increase in left ventricular systolic dimension and a decrease in fractional shortening under basal conditions

cellular

cardiac interstitial fibrosis ( J:110484 )

• seen in non-stressed 4-5 month old males

increased cardiac muscle cell glucose uptake ( J:110484 )

• myocardial basal glucose uptake is increased 5.5-fold