Phenotypes Associated with This Genotype

Genotype
MGI:3655833

• Allelic Composition: Lepr^db-3J/Lepr^db-3J
• Genetic Background: B6.129-Lepr^db-3J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

homeostasis/metabolism

abnormal glucose homeostasis ( J:78850 )

• Background Sensitivity: fasting mice at 3 months of age are euglycemic compaired to hyperglycemic obese mice on a congenic FVB background at 3 months

• Background Sensitivity: mice clear glucose load by 90 minutes, while on the FVB background, obese mice have severely impaired glucose tolerance

abnormal circulating glucose level ( J:78850 )

• Background Sensitivity: after a 2-day fast on refeeding with carbohydrate-free diet, female obese mice do not show a rise in glucose, while on the FVB background glucose levels increase

abnormal circulating insulin level ( J:78850 )

• Background Sensitivity: at 3 months, female obese mice have slightly lower insulin levels than FVB.BKS-Lepr^db females; levels increase to ~50 ng/ml at 5-7 months compared to ~500 ng/ml for obese FVB.BKS-Lepr^db females

increased insulin sensitivity ( J:78850 )

• in response to 3U/kg insulin, blood glucose drops 50% in 40 minutes while no change is seen in mice on the FVB background