Phenotypes Associated with This Genotype

Genotype
MGI:3655819

• Allelic Composition: Cyp1b1^tm1Gonz/Cyp1b1^tm1Gonz
• Genetic Background: involves: 129X1/SvJ * C57BL/6J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

vision/eye

abnormal iridocorneal angle ( J:82280 )

• angle abnormalities are present focally, detectable only by historical and electron microscopic analyses

• no gross abnormality observed

• intraocular pressure is indistinguishable from that of normal littermates

• in this mixed background, albino homozygous mice show more severe angle defects than pigmented homozygous mice

absent Schlemm's canal ( J:82280 )

• a small or absent Schlemm's canal

abnormal trabecular meshwork morphology ( J:82280 )

• basal lamina extends from the cornea over the trabecular meshwork

anterior iris synechia ( J:82280 )

• attachments of the iris to the trabecular meshwork and peripheral cornea

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
buphthalmos		DOID:11211	OMIM:231300	J:82280