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Phenotypes Associated with This Genotype
Genotype
MGI:3655819
Allelic
Composition
Cyp1b1tm1Gonz/Cyp1b1tm1Gonz
Genetic
Background
involves: 129X1/SvJ * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cyp1b1tm1Gonz mutation (3 available); any Cyp1b1 mutation (12 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
vision/eye
• angle abnormalities are present focally, detectable only by historical and electron microscopic analyses
• no gross abnormality observed
• intraocular pressure is indistinguishable from that of normal littermates
• in this mixed background, albino homozygous mice show more severe angle defects than pigmented homozygous mice
• a small or absent Schlemm's canal
• basal lamina extends from the cornea over the trabecular meshwork
• attachments of the iris to the trabecular meshwork and peripheral cornea

Mouse Models of Human Disease
OMIM ID Ref(s)
Glaucoma 3, Primary Congenital, A; GLC3A 231300 J:82280


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
08/23/2016
MGI 6.05
The Jackson Laboratory