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Phenotypes Associated with This Genotype
Genotype
MGI:3655819
Allelic
Composition
Cyp1b1tm1Gonz/Cyp1b1tm1Gonz
Genetic
Background
involves: 129X1/SvJ * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cyp1b1tm1Gonz mutation (3 available); any Cyp1b1 mutation (5 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
vision/eye
• angle abnormalities are present focally, detectable only by historical and electron microscopic analyses (J:82280)
• no gross abnormality observed (J:82280)
• intraocular pressure is indistinguishable from that of normal littermates (J:82280)
• in this mixed background, albino homozygous mice show more severe angle defects than pigmented homozygous mice (J:82280)
• angle abnormalities are present focally, detectable only by historical and electron microscopic analyses (J:82280)
• no gross abnormality observed (J:82280)
• intraocular pressure is indistinguishable from that of normal littermates (J:82280)
• in this mixed background, albino homozygous mice show more severe angle defects than pigmented homozygous mice (J:82280)
• a small or absent Schlemm's canal (J:82280)
• a small or absent Schlemm's canal (J:82280)
• basal lamina extends from the cornea over the trabecular meshwork (J:82280)
• basal lamina extends from the cornea over the trabecular meshwork (J:82280)
• attachments of the iris to the trabecular meshwork and peripheral cornea (J:82280)
• attachments of the iris to the trabecular meshwork and peripheral cornea (J:82280)

Mouse Models of Human Disease
OMIM ID Ref(s)
Glaucoma 3, Primary Congenital, A; GLC3A 231300 J:82280


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
02/02/2016
MGI 6.02
The Jackson Laboratory