Phenotypes Associated with This Genotype

Genotype
MGI:3655808

• Allelic Composition: Aqp4^tm1Ask/Aqp4^tm1Ask
• Genetic Background: B6.Cg-Aqp4^tm1Ask

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

hearing/vestibular/ear

deafness ( J:71154 )

• Background Sensitivity: hearing loss is more severe than in mice on a mixed C57BL/6 and CD-1 background

• on a congenic C57BL/6 background almost all mice are deaf

vision/eye

abnormal eye electrophysiology ( J:109783 )

• Background Sensitivity: b-wave amplitude and oscillatory potentials are reduced in mice on a C57BL/6 background but not in mice on a mixed CD-1 and C57BL/6 background

retina ischemia ( J:109783 )

• ischemia-induced impairment of b wave and oscillatory potential amplitudes is reduced compared to wild-type mice

• ischemia-induced decreases in retinal thickness and cellularity are reduced compared to wild-type mice; however, prior to ischemia no differences in retinal morphology are seen