Analysis Tools
mortality/aging
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• double homozygotes die within 3 weeks of birth, similar to single Bdnftm1Gdy homozygotes
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growth/size/body
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• double homozygotes display postnatal growth disturbances similar to those observed in single Bdnftm1Gdy homozygotes
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behavior/neurological
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• double homozygotes display behavioral defects similar to those observed in single Bdnftm1Gdy homozygotes
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hyperactivity
(
J:25565
)
nervous system
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• double homozygotes show a 79% reduction in the number of nodose-petrosal sensory neurons
• however, no reductions in the motor neurons of the facial nucleus or lumbar cord are observed
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• double homozygotes show a greater volume reduction in the nodose-petrosal complex (~83%, accompanied by a 79% reduction in neuronal number) relative to single Bdnftm1Gdy or Ntf5tm1Gdy homozygotes (~68% and ~61% reductions, respectively)
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• double mutant trigeminal ganglia are reduced by ~34% in volume relative to wild-type
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• double homozygotes show a greater volume reduction in the nodose-petrosal complex (~83%, accompanied by a 79% reduction in neuronal number) relative to single Bdnftm1Gdy or Ntf5tm1Gdy homozygotes (~68% and ~61% reductions, respectively)
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• at P1, double homozygotes display a comparable reduction in vestibular ganglion size relative to single Bdnftm1Gdy homozygotes
• in contrast to vestibular ganglia, cochlear ganglia and cochlear structures appear normal
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