Phenotypes Associated with This Genotype

Genotype
MGI:3654638

• Allelic Composition: Dbh^tm2(Th)Rpa/Dbh⁺; Th^tm5Rpa/Th^tm5Rpa
• Genetic Background: involves: 129S4/SvJaeSor * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

premature death ( J:110806 )

• without viral cre injection, phenotype is stated to be indistinguishable from mice homozygous for Th^tm1Rpa and heterozygous for Dbh^tm2(Th)Rpa

• mice die within 3 days of stopping L-DOPA treatment

behavior/neurological

aphagia ( J:110806 )

• in the absence of L-DOPA treatment

decreased locomotor activity ( J:110806 )

• severely hypoactive

bradykinesia ( J:110806 )

growth/size/body

decreased body weight ( J:110806 )

weight loss ( J:110806 )

• cessation of L-DOPA treatment results in weight loss

homeostasis/metabolism

decreased dopamine level ( J:110806 )

• dopamine levels are 0.56% of controls

• dopamine metabolite levels are also reduced

• evoked dopamine release in caudate putamen sections is absent