Phenotypes Associated with This Genotype

Genotype
MGI:3653873

• Allelic Composition: Tg(Ttr-Foxo1)305Dac/0
• Genetic Background: involves: FVB * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

homeostasis/metabolism

hyperglycemia ( J:79560 )

• fasting hyperglycemia at 2 months of age

decreased circulating insulin level ( J:79560 )

• normal at 2 months of age

• significantly lower than controls at 6 months of age in the fed state

impaired glucose tolerance ( J:79560 )

• at both 2 and 6 months of age

insulin resistance ( J:79560 )

• blunted insulin response to intraperitoneal glucose at 6 months of age

endocrine/exocrine glands

abnormal pancreatic beta cell morphology ( J:79560 )

• cross section area about 50% greater than in controls