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Phenotypes Associated with This Genotype
Genotype
MGI:3653871
Allelic
Composition		 Insrtm1Dac/Insr+
Irs2tm1Mfw/Irs2tm1Mfw
Genetic
Background		 involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Insrtm1Dac mutation (2 available); any Insr mutation (94 available)
Irs2tm1Mfw mutation (1 available); any Irs2 mutation (35 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging

homeostasis/metabolism
abnormal glucose homeostasis ( J:80826 )
• diabetic at 6 to 8 weeks of age

endocrine/exocrine glands
absent pancreatic beta cells ( J:80826 )
• undetectable at 8 weeks of age

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
04/30/2024
MGI 6.23 		The Jackson Laboratory