Phenotypes Associated with This Genotype

Genotype
MGI:3653865

• Allelic Composition: Foxl1^tm1Hfk/Foxl1^tm1Hfk
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

growth/size/body

decreased body size ( J:76379 )

• homozygotes show growth retardation up to 4 months of age, although birth weights are similar to wild-type

digestive/alimentary system

abnormal gastric gland morphology ( J:76379 )

• gastric glands are expanded and display disordered branching patterns

abnormal pyloric gastric gland morphology ( J:76379 )

• pyloric gland cells of mutants have reduced levels of pepsinogen

abnormal gastric chief cell morphology ( J:76379 )

• chief cell differentiation is almost completely suppressed in mutant stomachs

abnormal gastric parietal cell morphology ( J:76379 )

• when parietal cells from mutants are treated with histamine, little change is seen; when wild-type cells are treated, intracellular canaliculi are enlarged and connected to the luminal surface with wide openings

• some parietal cells in mutants lacked developed rough endoplasmic reticulum

increased stomach mucosa thickness ( J:76379 )

• gastric mucosa in adult homozygotes is 2- to 3-fold thicker than in wild-type; most cells in the upper half of the fundic mucosa demonstrate foveolar hyperplasias in the stomach

abnormal digestive secretion ( J:76379 )

• gastric acid secretion in mutant stomachs is almost completely suppressed

endocrine/exocrine glands

abnormal gastric gland morphology ( J:76379 )

• gastric glands are expanded and display disordered branching patterns

abnormal pyloric gastric gland morphology ( J:76379 )

• pyloric gland cells of mutants have reduced levels of pepsinogen

abnormal gastric chief cell morphology ( J:76379 )

• chief cell differentiation is almost completely suppressed in mutant stomachs

abnormal gastric parietal cell morphology ( J:76379 )

• when parietal cells from mutants are treated with histamine, little change is seen; when wild-type cells are treated, intracellular canaliculi are enlarged and connected to the luminal surface with wide openings

• some parietal cells in mutants lacked developed rough endoplasmic reticulum