Phenotypes Associated with This Genotype

Genotype
MGI:3653744

• Allelic Composition: Nfib^tm1Hsch/Nfib⁺
• Genetic Background: involves: 129S1/Sv * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

respiratory system

abnormal lung development ( J:75698 )

• heterozygous mutant lungs are arrested at the late canalicular stage with only focal transition of tissue to the terminal sac stage

• the already developed terminal sacs protect heterozygotes from death due to asphyxia; as a result, all heterozygotes survive and appear overtly normal

• continued postnatal maturation of lungs proceeds and lung histology is indistinguishable from that of wild-type mice at 8 weeks postpartum

abnormal lung saccule morphology ( J:75698 )

• at E18.5, only a few terminal sacs surrounded by thick mesenchyme are observed

thick lung-associated mesenchyme ( J:75698 )

• at E18.6, heterozygous mutant lungs display a larger mesenchymal compartment and thicker interalveolar septae

increased wet-to-dry lung weight ratio ( J:75698 )

• heterozygous mutant lungs have a 16% higher wet weight than wild-type lungs, despite normal size and lobation; however, no difference in lung dry weight is observed

pulmonary hypoplasia ( J:75698 )

• at E18.5 and shortly after birth, heterozygous mutant lungs are slightly hypoplastic and premature relative to wild-type lungs